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David Brooks

Toronto, Ontario

Position: Senior Scientist and Professor

Organization: Princess Margaret Cancer Center and University of Toronto

Dr. David Brooks is a Senior Scientist in the Tumor Immunotherapy Program at the Princess Margaret Cancer Center (PMCC), and a Professor in the Department of Immunology, Faculty of Medicine, at the University of Toronto. Dr. Brooks’ laboratory is focused on understanding the molecular mechanisms and cellular interactions that regulate immune responses in chronic infections and cancer. His group has shown that these diseases are associated with inflammation that counter-intuitively exacerbates immune dysfunction to promote disease progression. His goal is to use this information to design therapies that broadly restore immunity to fight infections and cancer. Before relocating to Canada, Dr. Brooks was a tenured Associate Professor and led a laboratory at University of California, Los Angeles (UCLA) for seven years. Dr. Brooks did his post-doctoral fellowship with Dr. Michael Oldstone at The Scripps Research Institute in La Jolla, California studying the immune response to chronic virus infection. Dr. Brooks earned his Ph.D. from UCLA under the mentorship of Dr. Jerome Zack, studying HIV latency and therapeutic strategies to reactivate the latent virus. Dr. Brooks earned his B.S. in Molecular and Cellular Biology from the University of Arizona. He was born and raised in Venice, California.

Areas of Expertise:

+ Tumor Immunology
+ Immunotherapy
+ Viral immunology

Language(s):

+ English


My Work

Ask me about:

Understanding the immune response to chronic infections and cancer, with a focus on inflammation, immunosuppression, and therapy.


About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

Title: Dr.

Gender: Male


Recent Publications

Title Year
Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer2022
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity2022
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection2021
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity2021
Immune profiling of advanced, recurrent metastatic endometrial cancer using high-dimensional time-of-flight mass cytometry (CyTOF)2021
Prevention of CD8 T Cell Deletion during Chronic Viral Infection2021
Uncovering the underlying immune perturbations that determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection2021
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells2021
Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection2021
Microbiome-Driven Tryptophan Metabolism Suppresses Immunity in the Pancreatic Tumor Microenvironment by Activation of the Aryl Hydrocarbon Receptor2021
The Role of Cytokine Signaling in the Reversal of Chronic Lymphedema2020
A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract2020
85: The Role of Cytokine Signaling in the Reversal of Chronic Lymphedema2020
Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection2020
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment2019
Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials2019
CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection2019
High dimensional analysis of the GI tract as a long-term reservoir for chronic viral infection2019
An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 (vol 176, pg 610, 2019)2019
Staphylococcus capitis Osteomyelitis: Case Report2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-102019
High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine2018
CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity2018
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses2018