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Alexander Baker: Profile Photo

Alexander Baker

Timberlea, Nova Scotia

Position: Assistant Professor

Organization: Dalhousie University

Dr. Alexander Baker is an Assistant Professor in the Department of Chemistry at Dalhousie University (July 2023). He pursued undergraduate studies (B.Sc.) as a combined Honors in Chemistry, Biochemistry at Dalhousie University, before proceeding to a PhD in Chemical Engineering and Applied Chemistry with a Collaborative Specialization in Biomedical Engineering. The focus of his research involved click chemistry hydrogels and 3D in vitro drug screening models for cancer with Dr. Molly Shoichet at the University of Toronto. As a postdoctoral fellow Dr. Baker concentrated on the design of an intraocular hydrogel to treat retinal detachment in Dr. Shoichet’s lab. He later joined Dr. Keith Pardee’s synthetic biology research group (University of Toronto) as a postdoctoral fellow. Here research focus included developing a multiplexed diagnostic and expansion of the genetic code with non-canonical amino acids for therapeutic applications.

Areas of Expertise:

+ Non-canonical amino acid synthesis
+ Conductive hydrogels
+ Cell-free protein expression

Language(s):

+ English


My Work

What I do:

Current research specializes in soft functional biomaterials and developing regenerative medicine treatments for retinal disease. In addition to protein therapeutics developed via cell-free incorporation of non-natural amino acids.

Ask me about:

Hydrogels can be used for or how cell-free protein expression works

Why me:

Interface between chemistry and materials and synthetic biology

Fun facts:

I collect Lego


About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

French proficiency: Read

Title: Dr.

Pronouns: He/Him/His

Gender: Male

Demographic: European / White


Recent Publications

Title Year
Chemically and mechanically defined hyaluronan hydrogels emulate the extracellular matrix for unbiased in vivo and in vitro organoid formation and drug testing in cancer2022
Temporally Controlled Photouncaged Epidermal Growth Factor Influences Cell Fate in Hydrogels2021
Synthesis of an Enzyme-Mediated Reversible Cross-linked Hydrogel for Cell Culture2021
Human Macrophage Invasion: Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior (Adv. Funct. Mater. 28/2021)2021
Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior2021
Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute2021
Nonswelling, Ultralow Content Inverse Electron‐Demand Diels–Alder Hyaluronan Hydrogels with Tunable Gelation Time: Synthesis and In Vitro Evaluation2020
Benchmarking to the Gold Standard: Hyaluronan‐Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture2019
Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High‐Content Drug Screening2018
Diels–Alder Click-Cross-Linked Hydrogels with Increased Reactivity Enable 3D Cell Encapsulation2018
Independently Tuning the Biochemical and Mechanical Properties of 3D Hyaluronan-Based Hydrogels with Oxime and Diels–Alder Chemistry to Culture Breast Cancer Spheroids2017
Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy2017
Hyaluronic acid-based hydrogels enhance isolated rod photoreceptor survival in vitro through mTOR activation2016
Transparent Porous Polysaccharide Cryogels Provide Biochemically Defined, Biomimetic Matrices for Tunable 3D Cell Culture2016
Hyaluronic Acid‐Based Hydrogels Enable Rod Photoreceptor Survival and Maturation In Vitro through Activation of the mTOR Pathway2016
The use of tin(IV) chloride to selectively cleave benzyl esters over benzyl ethers and benzyl amines2014
Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen2013
An Improved Method for the Synthesis of F-BODIPYs from Dipyrrins and Bis(dipyrrin)s2012
Use ofF-BODIPYs as a Protection Strategy for Dipyrrins: Optimization of BF2Removal2012