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Costin Antonescu: Profile Photo

Costin Antonescu

Toronto, Ontario

Position: Professor

Organization: Toronto Metropolitan University

I am a researcher in the field of cell biology with 20 years of experience. I study, teach and conduct research in fundamental and cancer cell biology. My research aims to reveal how signals from growth factor receptors and cell metabolism each control cell physiology, how these signals may contribute to diseases like cancer, and to identify new drugs and drug delivery strategies to treat these diseases.

Areas of Expertise:

+ Membrane traffic
+ Receptor signaling
+ Cell Metabolism

Language(s):

+ English

About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

French proficiency: Read, Speak

Title: Professor

Pronouns: He/Him/His

Gender: Male

Recent Publications

Title Year
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling2024
Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics2024
Cellular mechanisms of RET dysfunction in cancer cells2023
A tail of their own: regulation of cardiolipin and phosphatidylinositol fatty acyl profile by the acyltransferase LCLAT12023
Quantitative modeling of EGF receptor ligand discrimination via internalization proofreading2023
Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence2023
Measurement of GLUT4 Traffic to and from the Cell Surface in Muscle Cells2023
Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling2023
HER2 expression defines unique requirements for flotillin and c-Src in EGFR signaling2023
O-GlcNAc transferase modulates the cellular endocytosis machinery by controlling the formation of clathrin-coated pits2023
Doxycycline-inducible Expression of Proteins at Near-endogenous Levels in Mammalian Cells Using the Sleeping Beauty Transposon System2023
AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment2022
Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization2022
Single-colour, visible light activation and excitation of the luminescence of a ‘switch-on’ dye and enhancement by silver nanoparticles2022
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses2022
Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling2022
Single-Colour, Visible Light Activation and Excitation of the Luminescence of a ‘Switch-On’ Dye and Enhancement by Silver Nanoparticles2022
Facile supramolecular strategy to construct solid fluorophore@metal–organic framework composites2022
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease2021
Regulation of epidermal growth factor receptor signaling by clathrin-coated membrane microdomains2021
Regulation of Megalin membrane traffic by AMP‐activated protein kinase in kidney proximal tubule epithelial cells2021
Regulation of Epidermal Growth Factor Receptor by Clathrin‐Associated Kinases2021
Development of BODIPY labelled sialic acids as sialyltransferase substrates for direct detection of terminal galactose on N- and O-linked glycans2021
Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications2021
EGFR signaling in breast cancer requires licensing from separate membrane nanodomains2020