Canadian Sciences Speakers Network

Réseau Canadien de Panélistes Scientifiques

(Life Sciences) Biochemistry, Genetics and Molecular Biology — Cell Biology, (Life Sciences) Biochemistry, Genetics and Molecular Biology — Developmental Biology, (Life Sciences) Biochemistry, Genetics and Molecular Biology — Molecular Biology

Jean-Claude Labbé

Montréal, Quebec

Position: Full Professor at Université de Montréal

Organization: Université de Montréal

Following doctoral studies in biochemistry at the Université de Montréal under the direction of Luis A. Rokeach and Siegfried Hekimi, Jean-Claude Labbé carried out his first postdoctoral training in the Department of Biology of the University of North Carolina at Chapel Hill, in the United States, under the direction of Bob Goldstein, studying asymmetric division of embryonic cells in the nematode Caenorhabditis elegans. He then joined the laboratory of Monica Gotta at the Institute of Biochemistry, ETH Hönggerberg, in Zurich, Switzerland, for a second postdoctoral training focusing on the regulation of polarity in the C. elegans embryo. He was recruited by the IRIC in 2005 to continue his work on the fundamental mechanisms governing cell division during the course of animal development.

Areas of Expertise:

+ Mitosis and cytokinesis

+ Stem cell division

+ Actomyosin dynamics

Language(s):

+ English

+ French

My Work

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About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

French proficiency: Read, Write, Speak

Pronouns: He/Him/His

Gender: Male

Demographic: European / White

Recent Publications

Title	Year
The spatiotemporal distribution of LIN-5/NuMA regulates spindle orientation in the C. elegans germ line	2025
OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis	2024
Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy	2022
The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode C. elegans.	2022
The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae.	2021
The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis	2021
CentTracker: a trainable, machine-learning–based tool for large-scale analyses of Caenorhabditis elegans germline stem cell mitosis	2021
Expression pattern of endogenous PAR-4A & C after CRISPR/Cas9-mediated genome editing.	2018
Spindle assembly checkpoint strength is linked to cell fate in theCaenorhabditis elegansembryo	2018
Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells duringCaenorhabditis elegansembryogenesis	2017
DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation	2017
Investigating the Regulation of Stem and Progenitor Cell Mitotic Progression by In Situ Imaging	2015
CDK-1 and Two B-Type Cyclins Promote PAR-6 Stabilization during Polarization of the Early C. elegans Embryo	2015
Syncytium biogenesis: It’s all about maintaining good connections	2015
daf-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs inC. elegans	2015
C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization	2014
PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo	2014
RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4	2012
RAB-5 Controls the Cortical Organization and Dynamics of PAR Proteins to Maintain C. elegans Early Embryonic Polarity	2012
Live Imaging for Studying Asymmetric Cell Division in the C. elegans Embryo	2012
Characterization of the Mechanisms Controlling Greatwall Activity	2011
PAR-4/LKB1 Mobilizes Nonmuscle Myosin through Anillin to Regulate C. elegans Embryonic Polarization and Cytokinesis	2011
The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A	2010
Flattening and Cooling of Millimeter- and Micrometer-Sized Alumina Drops	2010
R43 Caractérisation des sites de phosphorylation de la nouvelle kinase Greatwall et leur implication dans le contrôle de la progression mitotique	2010

Filter Your Publications

Select Publications to Filter (119)

The spatiotemporal distribution of LIN-5/NuMA regulates spindle orientation in the C. elegans germ line

OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis

Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy

The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode C. elegans.

The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae.

The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis

CentTracker: a trainable, machine-learning–based tool for large-scale analyses of Caenorhabditis elegans germline stem cell mitosis

Expression pattern of endogenous PAR-4A & C after CRISPR/Cas9-mediated genome editing.

Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry

Spindle assembly checkpoint strength is linked to cell fate in theCaenorhabditis elegansembryo

Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells duringCaenorhabditis elegansembryogenesis

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

Laser surface treatment of porous ceramic substrate for application in solid oxide fuel cells

The master Greatwall kinase, a critical regulator of mitosis and meiosis

Investigating the Regulation of Stem and Progenitor Cell Mitotic Progression by In Situ Imaging

CDK-1 and Two B-Type Cyclins Promote PAR-6 Stabilization during Polarization of the Early C. elegans Embryo

Syncytium biogenesis: It’s all about maintaining good connections

daf-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs inC. elegans

C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization

PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo

RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4

RAB-5 Controls the Cortical Organization and Dynamics of PAR Proteins to Maintain C. elegans Early Embryonic Polarity

Live Imaging for Studying Asymmetric Cell Division in the C. elegans Embryo

Inhibition of PP2A prevents mitotic decoupling in the absence of CDK1 activity

Fabrication and characterization of ZrB2–SiC ceramic electrodes coated with a proton conducting, SiO2-rich glass layer

Greatwall, un nouveau gardien de la mitose

Characterization of the Mechanisms Controlling Greatwall Activity

PAR-4/LKB1 Mobilizes Nonmuscle Myosin through Anillin to Regulate C. elegans Embryonic Polarization and Cytokinesis

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

Flattening and Cooling of Millimeter- and Micrometer-Sized Alumina Drops

R43 Caractérisation des sites de phosphorylation de la nouvelle kinase Greatwall et leur implication dans le contrôle de la progression mitotique

Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

RSK2 is a kinetochore-associated protein that participates in the spindle assembly checkpoint

Differential requirements for STRAD in LKB1-dependent functions in C. elegans

Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability

Alumina Splat Investigation: Visualization of Impact and Splat/Substrate Interface for Millimeter-Sized Drops

Analytical solution of unsteady heat conduction in a two-layered material in imperfect contact subjected to a moving heat source

MAP Kinase Signaling Antagonizes PAR-1 Function During Polarization of the Early Caenorhabditis elegans Embryo

Greatwall maintains mitosis through regulation of PP2A

Alumina Splat Investigation: Visualization of Impact and Splat / Substrate Interface for Millimeter Sized Drops

Copper tracks processing on alumina by laser cladding: Elaboration and characterization

C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division

Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans

Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCFβtrcp

A Genomewide Screen for Suppressors of par-2 Uncovers Potential Regulators of PAR Protein-Dependent Cell Polarity in Caenorhabditis elegans

TiO-based coatings prepared by plasma spraying in air of Ti + C mixtures

Identification of parameters involved in the bonding of copper tracks on alumina substrates by a laser process

Comparison between two processes using oxygen in the Cu/AlN bonding

Influence of oxygen on the joining between copper and aluminium nitride

RELEVANT PARAMETERS FOR LASER BONDING OF COPPER ON ALUMINA

On the oxidation of stainless steel particles in the plasma jet

In-Flight Oxidation of Stainless Steel Particles in Plasma Spraying

Influence of substrate surface conditions on the plasma sprayed ceramic and metallic particles flattening

In-flight oxidation of iron particles sprayed using gas and water stabilized plasma torch

The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly

Kinetochore Localization of Spindle Checkpoint Proteins: Who Controls Whom?

Behaviour of the wettability of a SiAlON-base ceramic by molten steel

TiC Based Coatings Prepared by Combining SHS and Plasma Spraying

INVESTIGATION OF PHENOMENA INFLUENCING PROPERTIES OF PLASMA SPRAYED CERAMIC-METAL COMPOSITE DEPOSITS

Wettability and corrosion of AlN–BN–C ceramics by a SiCa treated liquid steel

Xkid Is Degraded in a D-Box, KEN-Box, and A-Box-Independent Pathway

In-Flight Oxidation of Metallic Particles in Plasma Spraying

PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans

INFLUENCE OF SUBSTRATE SURFACE OXIDATION STAGE ON THE MORPHOLOGY AND FLATTENING OF SPLATS

The D‐Box‐activating domain (DAD) is a new proteolysis signal that stimulates the silent D‐Box sequence of Aurora‐A

Initial activation of cyclin‐B1–cdc2 kinase requires phosphorylation of cyclin B1

A new role for Mos inXenopusoocyte maturation: targeting Myt1 independently of MAPK

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

Using RNA interference to identify genes required for RNA interference

Embryonic Development: A New SPN on Cell Fate Specification Dispatch

Contrôle de la transition métaphase-anaphase

CDK1-mediated phosphorylation of the RIIα regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIα from centrosomes at mitosis

Cyclin B/cdc2 Induces c-Mos Stability by Direct Phosphorylation inXenopusOocytes

Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

Wettability of non-reactive Cu/Si–Al–O–N systems I. Experimental results

Oxidation of Iron Particles During APS: Effect of the Process on Formed Oxide; Wetting of Droplets on Ceramic Substrates

The APC is dispensable for first meiotic anaphase in Xenopus oocytes

ROP-1, an RNA quality-control pathway component, affectsCaenorhabditis elegansdauer formation

Etude de la mouillabilite de l’invar par un email

Part of Xenopus Translin Is Localized in the Centrosomes during Mitosis

The polo-like kinase Plx1 prevents premature inactivation of the APCFizzy-dependent pathway in the early Xenopus cell cycle

Effect of metal particles oxidation during the APS on the wettability.

A possible link between posttranslational processing of ROP-1 and cleavage of the RoRNP-associated Y RNA during Caenorhabditis elegans larval development

Assessing the function of the Ro ribonucleoprotein complex usingCaenorhabditis elegansas a biological tool

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

cdk1- and cdk2-Mediated Phosphorylation of MyoD Ser200 in Growing C2 Myoblasts: Role in Modulating MyoD Half-Life and Myogenic Activity

The Levels of the RoRNP-Associated Y RNA Are Dependent Upon the Presence of ROP-1, the Caenorhabditis elegans Ro60 Protein

Assessing the function of the Ro ribonucleoprotein complex using<i> Caenorhabditis elegans</i> as a biological tool

Effect of Heating Cycle on the Structure of Ag Films Deposited over Porcelain Substrates

Mitosis-specific Phosphorylation and Subcellular Redistribution of the RIIα Regulatory Subunit of cAMP-dependent Protein Kinase

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

Molybdenum and tungsten coatings for x- ray targets obtained through the low-pressure plasma spraying process

Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity

Influence of boron nitride and carbon additives on the behaviour of sintered AlN in a steel-making environment

MAP kinase does not inactivate, but rather prevents the cyclin degradation pathway from being turned on in Xenopus egg extracts

Aluminium nitride—molybdenum ceramic matrix composites: Characterization of ceramic—Metal interface

Study of the behaviour of aluminium nitride in the iron and steel industry

The Caenorhabditis elegans rop-1 gene encodes the homologue of the human 60-kDa Ro autoantigen

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

Renforcement de la résistance de AIN à la corrosion face aux aciers.

Intrinsic microtubule stability in interphase cells

Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

Rôle du monoxyde de fer sur la mouillabilité du kovar par le verre

Study of the interaction between liquid aluminum and silicon nitride

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs

Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.

Mitotic cytosol inhibits invagination of coated pits in broken mitotic cells.

A major substrate of maturation promoting factor identified as elongation factor 1 beta gamma delta in Xenopus laevis

Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells.

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

Concerted Roles of Cyclin A, cdc25+ Mitotic Inducer, and Type 2A Phosphatase in Activating the Cyclin B/cdc2 Protein Kinase at the G2/M Phase Transition

[23] M phase-specific cdc2 kinase: Preparation from Starfish oocytes and properties

M‐phase‐specific cdc2 protein kinase phosphorylates the β subunit of casein kinase II and increases casein kinase II activity

Mitotic phosphorylation and disassembly of the nuclear lamina by cdc2 kinase

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