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Marc Therrien: Profile Photo

Marc Therrien

Montréal, Québec

Position: Professor

Organization: IRIC – Université de Montréal

Research in the field of signal tranduction with over 20 years of experience

Areas of Expertise:

+ Signal transduction
+ Molecular and cell biology
+ Structural biology and drug discovery

Language(s):

+ English
+ French

About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

French proficiency: Read, Write, Speak

Title: Dr.

Gender: Male

Demographic: European / White

Recent Publications

Title Year
RAS signaling gets granular2025
Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration2024
The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction2024
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae2023
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling2023
A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene2021
Functional characterization of a PROTAC directed against BRAF mutant V600E2020
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP12018
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect2018
MEK drives BRAF activation through allosteric control of KSR proteins2018
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition2017
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK2017
Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila2016
Inhibition of RAS function through targeting an allosteric regulatory site2016
The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila2016
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation2014
Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap12014
Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O2014
A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila2014
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization2013
The exon junction complex: A splicing factor for long intron containing transcripts?2011
The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila2010
Mécanisme d’activation de l’oncogèneBRAF2010
A dimerization-dependent mechanism drives RAF catalytic activation2009
The PP2C Alphabet Is a Negative Regulator of Stress-Activated Protein Kinase Signaling in Drosophila2008