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Sebastien Carreno

Montreal, Quebec

Position: Full Professor at Institute for Research in Immunology and Cancer

Organization: Université de Montréal

I obtained my Ph.D. in Molecular Biology from Université Toulouse III in 2001. Following postdoctoral training at the University of California, Berkeley, under the supervision of David G. Drubin, I joined François Payre’s team in 2005 to continue my training at Université de Toulouse. IRIC finally recruited me in 2008 as a Principal Investigator, Cellular Mechanisms of Morphogenesis Research Unit. Since September of 2017, I has also occupied the position of Director, Academic Affairs at IRIC.

Areas of Expertise:

+ Cell morphogenesis
+ Cell division and migration
+ Cell-cell communication through cytonemes

Language(s):

+ English
+ French


My Work

What I do:

We focus on the framework of cells, and more specifically on their cytoskeleton. The latter’s remodeling participates not only in cell division and motility, but is also involved in tumor development and metastasis. We focus on the nature of the interactions between two networks of filaments: actin filaments and tubulin filaments, also called microtubules. We strive to understand how those two networks take part in reorganizing the cell cortex at various stages of the mitosis, as well as during cell migration. To do so, the group uses functional genomics, cell biology and high resolution microscopy techniques in order to observe, in real time, the molecular interactions that shape the cytoskeleton during those processes.

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About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

French proficiency: Read, Write, Speak

Title: Professor

Pronouns: He/Him/His

Gender: Male

Demographic: European / White


Recent Publications

Title Year
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication2025
Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics2024
Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry2022
Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies2021
Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real time2021
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity2020
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay2020
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration2019
PTEN reduces endosomal PtdIns(4,5)P2 in a phosphatase-independent manner via a PLC pathway2019
IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis2019
Abstract 2355: Penile cancer in vitro models useful for the identification of targeted therapies2018
Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis2016
PHENOTYPICAL AND MOLECULAR CHARACTERIZATION OF CELL CULTURES DERIVED FROM USUAL PENILE CARCINOMAS.2016
Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis2014
DHTP is an allosteric inhibitor of the kinesin‐13 family of microtubule depolymerases2014
The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex2013
Abstract 5191: Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.2013
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility2013
The unexpected role of Drosophila OCRL during cytokinesis2012
Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis2011
The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis2011
Moesin keeps mitotic cells in shape2011
LRCH Proteins: A Novel Family of Cytoskeletal Regulators2010
Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation duringDrosophiladevelopment2010
Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells2008