Canadian Sciences Speakers Network

Réseau Canadien de Panélistes Scientifiques

Go Back

(Health Sciences) Medicine — Biochemistry

Walid A. Houry

Toronto

Position: Professor

Organization: University of Toronto

Dr. Walid A. Houry is Professor in the Department of Biochemistry and Department of Chemistry at the University of Toronto. Dr. Houry obtained his PhD from Cornell University and then did his postdoctoral training at the Sloan-Kettering Institute in New York City and at the Max-Planck-Institute for Biochemistry in Munich, Germany. He is interested in the general area of cellular stress responses and the role of molecular chaperones and proteases in these responses. His group is also interested in the development of novel anticancers, antibiotics, and antivirals by identifying compounds that target these chaperones and proteases and result in the dysregulation of protein homeostasis in the cell. He has been recognized with national and international awards including awards from the Tokyo Biochemical Research Foundation (2011), the National Research Foundation of South Africa (2015), the Sigma Xi Scientific Research Honor Society (2021), and OIC-COMSTECH Distinguished Scholar Program, Islamabad, Pakistan (2022). He is typically invited to present at several conferences per year. He is currently the President of the Canadian Society for Molecular Biosciences.

Areas of Expertise:

+ Protein quality control

+ Drug discovery

+ Protein biochemistry

Language(s):

+ English

+ Arabic

My Work

What I do:

My research is in the area of protein quality control. We study molecular chaperones and ATP-dependent proteases. I am also interested in contributing to University governance and to Scientific societies.

Ask me about:

Drug discovery (antibiotics, anticancers) Science in Canada Scientific publishing Scientific societies

Why me:

I have been actively involved in these areas.

About Me

Sector: Academia (Post Secondary)

English proficiency: Read, Write, Speak

Other Language(s): Arabic

Title: Professor

Pronouns: He/Him/His

Gender: Male

Demographic: West Asian

Recent Publications

Title	Year
Tuning TCR complex recruitment to the T cell antigen coupler (TAC) enhances TAC-T cell function	2025
Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies	2024
Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases	2024
Target-locked: A mechanism for disaggregase binding to aggregated proteins	2024
Abstract 1205 The mitochondrial ClpP protease: from basic principles to drug discovery	2024
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling	2024
Second international symposium on the chaperone code, 2023	2024
Broad spectrum post-entry inhibitors of coronavirus replication: Cardiotonic steroids and monensin	2023
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine	2023
The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme	2023
Unveiling the Role of Sorghum RPAP3 in the Function of R2TP Complex: Insights into Protein Assembly in Plants	2023
Abstract 3843: Potent human ClpP protease agonists with anticancer properties bind the enzyme with improved structural complementarity and alter the mitochondrial N-terminome	2023
Toward protein fingerprinting with a solid-state nanopore	2023
Abstract 1267: The Role of Hsp90-R2TP in Ciliogenesis	2023
Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8–9, 2022	2023
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome	2022
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP	2022
Analysis of the Evolution of the MoxR ATPases	2022
Assembly Principles of the Human R2TP Chaperone Complex Reveal the Presence of R2T and R2P Complexes	2022
Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes	2022
The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation	2021
Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex	2021
Functional Cooperativity between the Trigger Factor Chaperone and the ClpXP Proteolytic Complex	2021
Leishmania major RUVBL1 has a hexameric conformation in solution and, in the presence of RUVBL2, forms a heterodimer with ATPase activity	2021
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex	2021

Filter Your Publications

Select Publications to Filter (114)

Tuning TCR complex recruitment to the T cell antigen coupler (TAC) enhances TAC-T cell function

Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies

Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases

Target-locked: A mechanism for disaggregase binding to aggregated proteins

Abstract 1205 The mitochondrial ClpP protease: from basic principles to drug discovery

DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling

Second international symposium on the chaperone code, 2023

Broad spectrum post-entry inhibitors of coronavirus replication: Cardiotonic steroids and monensin

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine

The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme

Unveiling the Role of Sorghum RPAP3 in the Function of R2TP Complex: Insights into Protein Assembly in Plants

Abstract 3843: Potent human ClpP protease agonists with anticancer properties bind the enzyme with improved structural complementarity and alter the mitochondrial N-terminome

Toward protein fingerprinting with a solid-state nanopore

Abstract 1267: The Role of Hsp90-R2TP in Ciliogenesis

Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8–9, 2022

Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

Analysis of the Evolution of the MoxR ATPases

Assembly Principles of the Human R2TP Chaperone Complex Reveal the Presence of R2T and R2P Complexes

Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

Functional Cooperativity between the Trigger Factor Chaperone and the ClpXP Proteolytic Complex

Leishmania major RUVBL1 has a hexameric conformation in solution and, in the presence of RUVBL2, forms a heterodimer with ATPase activity

Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex

Purification and characterization of a novel and conserved TPR-domain protein that binds both Hsp90 and Hsp70 and is expressed in all developmental stages of Leishmania major

Development of Antibiotics That Dysregulate the Neisserial ClpP Protease

Sorafenib as an Inhibitor of RUVBL2

Heat shock protein 90 kDa (Hsp90) from Aedes aegypti has an open conformation and is expressed under heat stress

AAA+ proteins

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Strategies for purification of the bacteriophage HK97 small and large terminase subunits that yield pure and homogeneous samples that are functional

Molecular Basis of ClpP Protease Activation by Small Molecules

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

Dysregulation of Human Mitochondrial ClpP Protease Activity by Acyldepsipeptides Analogs Leads to Apoptotic Cell Death

Systems analysis of the genetic interaction network of yeast molecular chaperones

Computational Analysis of the Chaperone Interaction Networks

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

Chaperoning the Proteome

The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex

Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA

Functional Cooperativity Between the Trigger Factor Chaperone and the ClpXP Degradation System

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors

Nutritional Status Modulates Box C/D snoRNP Biogenesis by Regulated Subcellular Relocalization of the R2TP Complex

Yeast Rvb1 and Rvb2 Proteins Oligomerize As a Conformationally Variable Dodecamer with Low Frequency

Correction: Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

Novel function discovery with GeneMANIA: a new integrated resource for gene function prediction in Escherichia coli

Total Synthesis and Antibacterial Testing of the A54556 Cyclic Acyldepsipeptides Isolated from Streptomyces hawaiiensis

Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex

Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in Escherichia coli

The MoxR ATPase RavA and Its Cofactor ViaA Interact with the NADH:Ubiquinone Oxidoreductase I in Escherichia coli

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA

The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape Meeting Information: The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2) took place at the European Institute for Chemistry and Biology in Pessac, France, 16 to 19 October 2012.

Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

The Stability of the Small Nucleolar Ribonucleoprotein (snoRNP) Assembly Protein Pih1 in Saccharomyces cerevisiae Is Modulated by Its C Terminus

Hsp110 is required for spindle length control

The role of Hsp90‐R2TP complex in snoRNP assembly and ribosomal RNA processing

Role of the N-Terminal Domain of the Chaperone ClpX in the Recognition and Degradation of Lambda Phage Protein O

Mapping the molecular chaperone interaction network in yeast

Insights into the mechanism of function of a protein unfolding and degradation system

Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90

The Enzymatic Activities of the Escherichia coli Basic Aliphatic Amino Acid Decarboxylases Exhibit a pH Zone of Inhibition

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase

Bioinformatic Approach to Identify Chaperone Pathway Relationship from Large-Scale Interaction Networks

An Assay for Measuring the Activity of <em>Escherichia coli</em> Inducible Lysine Decarboxyase

Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity

Alternative Oligomeric States of the Yeast Rvb1/Rvb2 Complex Induced by Histidine Tags

The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum

Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations

Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity

The Genetic Landscape of a Cell

Introduction / Introduction

Single molecule study of ClpP enzymatic activity

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae : implications to protein folding pathways in the cell

Crystallization and preliminary X-ray analysis of the inducible lysine decarboxylase fromEscherichia coli

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

Yeast Rvb1 and Rvb2 are ATP-Dependent DNA Helicases that Form a Heterohexameric Complex

Overview of prokaryotic molecular chaperones

Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX

Large nucleotide-dependent movement of the N-terminal domain of the ClpX chaperone

MoxR AAA+ ATPases: A novel family of molecular chaperones?

Formation of a Distinctive Complex between the Inducible Bacterial Lysine Decarboxylase and a Novel AAA+ ATPase

Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release

Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone

The ClpP Double Ring Tetradecameric Protease Exhibits Plastic Ring-Ring Interactions, and the N Termini of Its Subunits Form Flexible Loops That Are Essential for ClpXP and ClpAP Complex Formation

Chaperone networks in bacteria: analysis of protein homeostasis in minimal cells

The N-terminal Zinc Binding Domain of ClpX Is a Dimerization Domain That Modulates the Chaperone Function

Solution Structure of the Dimeric Zinc Binding Domain of the Chaperone ClpX

Phylogenetic Web Profiler

Mechanism of substrate recognition by the chaperonin GroEL

Molecular chaperones in protein folding in the cell

Identification of in vivo substrates of the chaperonin GroEL

Polypeptide Flux through Bacterial Hsp70

Definition of amide protection factors for early kinetic intermediates in protein folding

In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System

Structure of a Hydrophobically Collapsed Intermediate on the Conformational Folding Pathway of Ribonuclease A Probed by Hydrogen−Deuterium Exchange

Kinetic and Thermodynamic Studies of the Folding/Unfolding of a Tryptophan-Containing Mutant of Ribonuclease A

Circular Dichroism Evidence for the Presence of Burst-Phase Intermediates on the Conformational Folding Pathway of Ribonuclease A

Nature of the Unfolded State of Ribonuclease A: Effect of Cis−Trans X−Pro Peptide Bond Isomerization

The nature of the initial step in the conformational folding of disulphide-intact ribonuclease A

A Very Fast Phase in the Refolding of Disulfide-Intact Ribonuclease A: Implications for the Refolding and Unfolding Pathways

You must be logged in to edit your publications